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Article

Lack of an association between SCFD1 rs10139154 polymorphism and amyotrophic lateral sclerosis.

Molecular medicine reports - 1 Apr 2022

Siokas Vasileios, Aloizou Athina-Maria, Liampas Ioannis, Bakirtzis Christos, Nasios Grigorios, Paterakis Konstantinos, Sgantzos Markos, Bogdanos Dimitrios P, Spandidos Demetrios A, Tsatsakis Aristidis, Mitsias Panayiotis D, Dardiotis Efthimios

Abstract excerpt

Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease. Through a genome‑wide association study (GWAS), the Sec1 family domain‑containing protein 1 (SCFD1) rs10139154 variant at 14q12 has emerged as a risk factor gene for ALS. Moreover, it has been reported to influence the age at onset (AAO) of patients with ALS. The aim of the present study was to assess the association of the SCFD1...

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Identifiers

PMID: 35234271
DOI: 10.3892/mmr.2022.12662
PMCID: PMC8915390

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