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Article

Conditional inactivation of Aspergillus nidulans sarA(SAR1) uncovers the morphogenetic potential of regulating endoplasmic reticulum (ER) exit.

Molecular microbiology - 1 Feb 2015

Hernández-González Miguel, Peñalva Miguel A, Pantazopoulou Areti

Abstract excerpt

In the genetic model Aspergillus nidulans, hyphal growth is exquisitely dependent on exocytic traffic. Following mutagenic PCR and gene replacement, we characterized thermosensitive mutations in sarA(SAR1) encoding a key regulator of endoplasmic reticulum (ER) exit. Six sarA(ts) alleles permitting relatively normal growth at 30°C prevented it at 42°C. This growth phenotype correlated with markedly reduced SarA...

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PMID: 25425159
DOI: 10.1111/mmi.12880

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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