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Article

Overexpression of YPT6 restores invasive filamentous growth and secretory vesicle clustering in a Candida albicans arl1 mutant.

Small GTPases - 1 May 2020

Wakade Rohan, Labbaoui Hayet, Stalder Danièle, Arkowitz Robert A, Bassilana Martine

Abstract excerpt

Virulence of the human fungal pathogen Candida albicans depends on the switch from budding to filamentous growth. Deletion of the Arf GTPase Arl1 results in hyphae that are shorter as well as reduced virulence. How Arl1 is regulated during hyphal growth, a process characteristic of filamentous fungi, yet absent in S. cerevisiae, is unknown. Here, we investigated the importance of the Rab6 homolog, Ypt6, in...

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Identifiers

PMID: 28960163
DOI: 10.1080/21541248.2017.1378157
PMCID: PMC7549723

Genes

ARL1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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