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Article

Association of the p22phox polymorphism C242T with the risk of late-onset Alzheimer's disease in a northern Han Chinese population.

The International journal of neuroscience - 1 Jan 2016

Fu Qingxi, Qi Faying, Tian Fengyun, Ma Guozhao, Che Fengyuan, Du Yifeng, Gao Naiyong

Abstract excerpt

The C242T polymorphism of the CYBA gene that encodes p22phox, a component of nicotinamide adenine dinucleotide phosphate oxidase, has been found to modulate reactive oxygen species (ROS) production. Oxidative stress is thought to play a pivotal role in the pathophysiology of Alzheimer's disease (AD), which is manifested as increased availability of ROS because of an imbalanced redox state. Therefore, the aim of...

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Source

Identifiers

PMID: 26000926
DOI: 10.3109/00207454.2015.1052877

Genes

CYBA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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