Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Role of Wdr45b in maintaining neural autophagy and cognitive function

25 Jun 2019

Abstract excerpt

Macroautophagy/autophagy functions as a quality control mechanism by degrading misfolded proteins and damaged organelles and plays an essential role in maintaining neural homeostasis. The phosphoinositide phosphatidylinositol-3-phosphate (PtdIns3P) effector Atg18 is essential for autophagosome formation in yeast. Mammalian cells contain four Atg18 homologs, belonging to two subclasses, WIPI1 (WD repeat domain,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Autophagy in Disease and Therapy
Share to Endoplasmic Reticulum Stress and Disease
Share to Studies on Chitinases and Chitosanases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 31238825
DOI: 10.1080/15548627.2019.1632621

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Role of Wdr45b in maintaining neural autophagy and cognitive functionPMID 31238825Read ↗

The autophagy gene Wdr45/Wipi4 regulates learning and memory function and axonal homeostasis.Semantic proximity Read ↗

The BPAN and intellectual disability disease proteins WDR45 and WDR45B modulate autophagosome-lysosome fusionSemantic proximity Read ↗

AAV-mediated gene transfer of WDR45 corrects neurologic deficits in the mouse model of beta-propeller protein-associated neurodegenerationSemantic proximity Read ↗

Physiological Significance of WDR45, A Responsible Gene for β-propeller Protein Associated Neurodegeneration (BPAN), in Brain DevelopmentSemantic proximity Read ↗

A <i>dwdr45</i> knock-out <i>Drosophila</i> model to decipher the role of autophagy in BPANSemantic proximity Read ↗

WDR45 contributes to neurodegeneration through regulation of ER homeostasis and neuronal deathSemantic proximity Read ↗

A dwdr45 knock-out drosophila model to decipher the role of autophagy in BPAN.Semantic proximity Read ↗

A neurodegeneration gene, WDR45, links impaired ferritinophagy to iron accumulationSemantic proximity Read ↗

Human WIPI β-propeller function in autophagy and neurodegeneration.Semantic proximity Read ↗

A comprehensive phenotypic characterization of a whole-body Wdr45 knock-out mouse.Semantic proximity Read ↗

WIPI proteins: Biological functions and related syndromesSemantic proximity Read ↗

WDR45 contributes to neurodegeneration through regulation of ER homeostasis and neuronal deathSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.