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Article

Structure and properties of G84R and L99M mutants of human small heat shock protein HspB1 correlating with motor neuropathy.

Archives of biochemistry and biophysics - 1 Oct 2013

Nefedova Victoria V, Sudnitsyna Maria V, Strelkov Sergei V, Gusev Nikolai B

Abstract excerpt

Some properties of G84R and L99M mutants of HspB1 associated with peripheral distal neuropathies were investigated. Homooligomers formed by these mutants are larger than those of the wild type HspB1. Large oligomers of G84R and L99M mutants have compromised stability and tend to dissociate at low protein concentration. G84R and L99M mutations promote phosphorylation-dependent dissociation of HspB1 oligomers...

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Identifiers

PMID: 23948568
DOI: 10.1016/j.abb.2013.07.028

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