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Article

The Toll-like receptor 4 D299G and T399I polymorphisms are associated with Crohn's disease and ulcerative colitis: a meta-analysis.

Digestion - 1 Jan 2010

Shen Xiuyun, Shi Ruihua, Zhang Hongjie, Li Kebei, Zhao Yang, Zhang Ruyang

Abstract excerpt

BACKGROUND: Some studies have reported that Toll-like receptor 4 (TLR4) D299G and T399I polymorphisms are associated with increased Crohn's disease (CD) and ulcerative colitis (UC) risk in the Caucasian population. However, the results have been inconsistent. METHODS: A systemic review of the published data (16 studies with 8,387 cases and 7,013 controls for D299G; 8 studies with 3,881 cases and 1,861 controls...

Topics

Alleles
Colitis, Ulcerative
Crohn Disease
Genetic Predisposition to Disease
Humans
Phenotype
Polymorphism, Genetic
Toll-Like Receptor 4
White People

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 20093834
DOI: 10.1159/000260417

Genes

TLR4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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