Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Gene targeting by TALEN-induced homologous recombination in goats directs production of β-lactoglobulin-free, high-human lactoferrin milk.

Scientific reports - 21 May 2015

Cui Chenchen, Song Yujie, Liu Jun, Ge Hengtao, Li Qian, Huang Hui, Hu Linyong, Zhu Hongmei, Jin Yaping, Zhang Yong

Abstract excerpt

β-Lactoglobulin (BLG) is a major goat's milk allergen that is absent in human milk. Engineered endonucleases, including transcription activator-like effector nucleases (TALENs) and zinc-finger nucleases, enable targeted genetic modification in livestock. In this study, TALEN-mediated gene knockou...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Deoxyribonucleases
Share to Gene Knock-In Techniques
Share to Gene Targeting

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Homologous Recombination

Share to Lactoferrin

Share to Lactoglobulins

Source

Open in PubMed Open full text

Identifiers

PMID: 25994151
DOI: 10.1038/srep10482
PMCID: PMC5386245

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-25994151-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Gene targeting by TALEN-induced homologous recombination in goats directs production of β-lactoglobulin-free, high-human lactoferrin milk.PMID 25994151Read ↗

Targeting Human α-Lactalbumin Gene Insertion into the Goat β-Lactoglobulin Locus by TALEN-Mediated Homologous Recombination.Semantic proximity Read ↗

Generation of β-lactoglobulin-modified transgenic goats by homologous recombination.Semantic proximity Read ↗

Production of hypoallergenic milk from DNA-free beta-lactoglobulin (BLG) gene knockout cow using zinc-finger nucleases mRNASemantic proximity Read ↗

Production of microhomologous-mediated site-specific integrated LacS gene cow using TALENs.Semantic proximity Read ↗

Impact of CRISPR-Cas9-Based Genome Engineering in Farm AnimalsSemantic proximity Read ↗

Efficient introgression of allelic variants by embryo-mediated editing of the bovine genome.Semantic proximity Read ↗

Efficient TALEN-mediated gene knockout in livestock.Semantic proximity Read ↗

Genome targeting by hybrid Flp-TAL recombinases.Semantic proximity Read ↗

Toward Altering Milk Composition by Genetic Manipulation: Current Status and ChallengesSemantic proximity Read ↗

Genomic Tools for Medicinal Properties of Goats Milk for Cosmetic and Health Benefits. A ReviewSemantic proximity Read ↗

Gene cloning and seamless site-directed mutagenesis using single-strand annealing (SSA).Semantic proximity Read ↗

Editing livestock genomes with site-specific nucleases.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.