Article
Generation of β-lactoglobulin-modified transgenic goats by homologous recombination.
The FEBS journal - 1 Dec 2016
Zhu Hongmei, Hu Linyong, Liu Jun, Chen Huatao, Cui Chenchen, Song Yujie, Jin Yaping, Zhang Yong
Abstract excerpt
β-Lactoglobulin (BLG) is a dominant allergen present in the milk of goats and other ungulates, although it is not found in human breast milk. Thus, the presence of BLG restricts the consumption of goat's milk by humans. In the present study, we examined whether the disruption of the BLG gene in goats by homologous recombination (HR) reduced BLG content in goat's milk and decreased the allergic response to milk....
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