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Article

Decreased mutation frequencies among immunoglobulin G variable region genes during viremic HIV-1 infection.

PloS one - 1 Jan 2014

Bowers Elisabeth, Scamurra Ronald W, Asrani Anil, Beniguel Lydie, MaWhinney Samantha, Keays Kathryne M, Thurn Joseph R, Janoff Edward N

Abstract excerpt

BACKGROUND/OBJECTIVE: HIV-1 infection is complicated by high rates of opportunistic infections against which specific antibodies contribute to immune defense. Antibody function depends on somatic hypermutation (SHM) of variable regions of immunoglobulin heavy chain genes (VH-D-J). We characterized the frequency of SHM in expressed IgG mRNA immunoglobulin transcripts from control and HIV-1-infected patients....

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 24409278
DOI: 10.1371/journal.pone.0081913
PMCID: PMC3883639

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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