Article
Transient Blockade of ERK Phosphorylation in the Critical Period Causes Autistic Phenotypes as an Adult in Mice.
Scientific reports - 20 May 2015
Yufune Shinya, Satoh Yasushi, Takamatsu Isao, Ohta Hiroyuki, Kobayashi Yasushi, Takaenoki Yumiko, Pagès Gilles, Pouysségur Jacques, Endo Shogo, Kazama Tomiei
Abstract excerpt
The critical period is a distinct time-window during the neonatal stage when animals display elevated sensitivity to certain environmental stimuli, and particular experiences can have profound and long-lasting effects on behaviors. Increasing evidence suggests that disruption of neuronal activity during the critical period contributes to autistic phenotype, although the pathogenic mechanism is largely unknown....
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