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Article

Congenital hypothyroidism alters the phosphorylation of ERK1/2 and p38MAPK in the hippocampus of neonatal rats.

Brain research. Developmental brain research - 1 Jan 2005

Calloni Giordano W, Penno Carlos A, Cordova Fabiano M, Trentin Andréa Gonçalves, Neto Vivaldo Moura, Leal Rodrigo Bainy

Abstract excerpt

Thyroid hormone deficiency during the critical period of neural differentiation produces permanent and severe alterations in the morphology and function of the nervous system leading to cretinism. Perinatal hypothyroidism results in permanent alterations of hippocampal synaptic functions in adult rats consequently causing learning and memory impairment. Mitogen-activated protein kinases (MAPKs) are a family of...

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PMID: 15617763
DOI: 10.1016/j.devbrainres.2004.10.005

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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