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Minor Type IV Collagen α5 Chain Promotes Cancer Progression through Discoidin Domain Receptor-1

19 May 2015

Abstract excerpt

Type IV collagens (Col IV), components of basement membrane, are essential in the maintenance of tissue integrity and proper function. Alteration of Col IV is related to developmental defects and diseases, including cancer. Col IV α chains form α1α1α2, α3α4α5 and α5α5α6 protomers that further form collagen networks. Despite knowledge on the functions of major Col IV (α1α1α2), little is known whether minor Col IV...

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PMID: 25992553
DOI: 10.1371/journal.pgen.1005249

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