Article
Two polymorphisms in the Cx40 promoter are associated with hypertension and left ventricular hypertrophy preferentially in men.
Clinical and experimental hypertension (New York, N.Y. : 1993) - 1 Jan 2015
Schmidt Kjestine, Kaiser Frank J, Erdmann Jeanette, Wit Cor de
Abstract excerpt
BACKGROUND: Lack of connexin40, a gap junction protein expressed in endothelial and renin-producing cells, results in hypertension and cardiac hypertrophy in mice due to unleashed renin production caused by disruption of the pressure-induced feedback inhibition. We analysed human GJA5 consisting of two exons (exon1A or 1B and exon2) in a selected cohort identified by a single nucleotide polymorphism (SNP) in the...
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