Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Loss of functional endothelial connexin40 results in exercise-induced hypertension in mice.

Hypertension (Dallas, Tex. : 1979) - 1 Mar 2015

Morton Susan K, Chaston Daniel J, Howitt Lauren, Heisler Jillian, Nicholson Bruce J, Fairweather Stephen, Bröer Stefan, Ashton Anthony W, Matthaei Klaus I, Hill Caryl E

Abstract excerpt

During activity, coordinated vasodilation of microcirculatory networks with upstream supply vessels increases blood flow to skeletal and cardiac muscles and reduces peripheral resistance. Endothelial dysfunction in humans attenuates activity-dependent vasodilation, resulting in exercise-induced hypertension in otherwise normotensive individuals. Underpinning activity-dependent hyperemia is an ascending...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Connexins
Share to Endothelium, Vascular

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gap Junction alpha-5 Protein

Share to Gap Junctions

Share to Heart Rate

Share to In Vitro Techniques

Share to Physical Conditioning, Animal

Share to Vasodilation

Source

Identifiers

PMID: 25547341
DOI: 10.1161/HYPERTENSIONAHA.114.04578

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Loss of functional endothelial connexin40 results in exercise-induced hypertension in mice.PMID 25547341Read ↗

Defective Cx40 Maintains Cx37 Expression but Intact Cx40 Is Crucial for Conducted Dilations Irrespective of HypertensionSemantic proximity Read ↗

Lack of vascular connexin 40 is associated with hypertension and irregular arteriolar vasomotion.Semantic proximity Read ↗

Activation of KCa3.1 by SKA-31 induces arteriolar dilatation and lowers blood pressure in normo- and hypertensive connexin40-deficient mice.Semantic proximity Read ↗

Connexins: Key Players in the Control of Vascular Plasticity and Function.Semantic proximity Read ↗

Connexin 43 Plays a Role in Pulmonary Vascular Reactivity in Mice.Semantic proximity Read ↗

Two polymorphisms in the Cx40 promoter are associated with hypertension and left ventricular hypertrophy preferentially in men.Semantic proximity Read ↗

Gap junctions and the connexin protein family.Semantic proximity Read ↗

Central role of connexin40 in the propagation of electrically activated vasodilation in mouse cremasteric arterioles in vivo.Semantic proximity Read ↗

Aging affects K <sub>V</sub> 7 channels and perivascular-adipose tissue-mediated vascular toneSemantic proximity Read ↗

Exercise assessment of transgenic models of human cardiovascular diseaseSemantic proximity Read ↗

Endothelial Connexin37 and Connexin40 participate in basal but not agonist-induced NO release.Semantic proximity Read ↗

The connexin 40 A96S mutation causes renin-dependent hypertension.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.