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Untouched GMP-Ready Purified Engineered Immune Cells to Treat Cancer

19 May 2015

Abstract excerpt

PURPOSE: Engineering T cells with receptors to redirect the immune system against cancer has most recently been described as a scientific breakthrough. However, a main challenge remains the GMP-grade purification of immune cells selectively expressing the introduced receptor in order to reduce potential side effects due to poorly or nonengineered cells. EXPERIMENTAL DESIGN: In order to test a novel purification...

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PMID: 25991821
DOI: 10.1158/1078-0432.ccr-14-2860

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