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Zebrafish cerebrospinal fluid mediates cell survival through a retinoid signaling pathway

15 May 2015

Abstract excerpt

Cerebrospinal fluid (CSF) includes conserved factors whose function is largely unexplored. To assess the role of CSF during embryonic development, CSF was repeatedly drained from embryonic zebrafish brain ventricles soon after their inflation. Removal of CSF increased cell death in the diencephalon, indicating a survival function. Factors within the CSF are required for neuroepithelial cell survival as injected...

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PMID: 25980532
DOI: 10.1002/dneu.22300

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