Article
An Ultra-Deep Targeted Sequencing Gene Panel Improves the Prognostic Stratification of Patients With Advanced Oral Cavity Squamous Cell Carcinoma.
Medicine - 1 Feb 2016
Liao Chun-Ta, Chen Shu-Jen, Lee Li-Yu, Hsueh Chuen, Yang Lan-Yan, Lin Chien-Yu, Fan Kang-Hsing, Wang Hung-Ming, Ng Shu-Hang, Lin Chih-Hung, Tsao Chung-Kan, Chen I-How, Chang Kai-Ping, Huang Shiang-Fu, Kang Chung-Jan, Chen Hua-Chien, Yen Tzu-Chen
Abstract excerpt
An improved prognostic stratification of patients with oral cavity squamous cell carcinoma (OSCC) and pathologically positive (pN+) nodes is urgently needed. Here, we sought to examine whether an ultra-deep targeted sequencing (UDT-Seq) gene panel may improve the prognostic stratification in this patient group.A mutation-based signature affecting 10 genes (including genetic mutations in 6 oncogenes and 4 tumor...
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