Article
A rare co-segregation-mutation in the insulin receptor substrate 1 gene in one Chinese family with ankylosing spondylitis.
PloS one - 1 Jan 2015
Rong Ju, Li Qiuxia, Zhang Pingping, Wu Xinyu, Huang Jinxian, Li Chao, Liao Zetao, Xie Yingying, Lv Qing, Wei Qiujing, Li Tianwang, Huang Jianlin, Cao Shuangyan, Shen Yan, Gu Jieruo
Abstract excerpt
Ankylosing spondylitis (AS; MIM 106300) is a common rheumatic disease with strong genetic components affecting approximately 0.3% of the population. The exact genetic mechanism of AS remains elusive. Our previous study showed that AS could be transmitted in an autosomal dominant inheritance mode...
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