Article
Rare SNP rs12731181 in the miR-590-3p Target Site of the Prostaglandin F2α Receptor Gene Confers Risk for Essential Hypertension in the Han Chinese Population.
Arteriosclerosis, thrombosis, and vascular biology - 1 Jul 2015
Xiao Bing, Gu Shui-Ming, Li Mulin Jun, Li Jun, Tao Bo, Wang Yuanyang, Wang Yan, Zuo Shengkai, Shen Yujun, Yu Yu, Chen Di, Chen Guilin, Kong Deping, Tang Juan, Liu Qian, Chen Dong-Rui, Liu Yong, Alberti Sara, Dovizio Melania, Landolfi Raffaele, Mucci Luciana, Miao Pei-Zhi, Gao Pingjin, Zhu Ding-Liang, Wang Junwen, Li Bin, Patrignani Paola, Yu Ying
Abstract excerpt
OBJECTIVE: To investigate whether rs12731181 (A→G) interrupted miR-590-3p-mediated suppression of the prostaglandin F2α receptor (FP) and whether it is associated with essential hypertension in the Chinese population. APPROACH AND RESULTS: We found that miR-590-3p regulates human FP gene expression by binding to its 3'-untranslated region. rs12731181 (A→G) altered the binding affinity between miR-590-3p and its...
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