Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The Role of Oxidized Cholesterol in Diabetes-Induced Lysosomal Dysfunction in the Brain.

Molecular neurobiology - 1 May 2016

Sims-Robinson Catrina, Bakeman Anna, Rosko Andrew, Glasser Rebecca, Feldman Eva L

Abstract excerpt

Abnormalities in lysosomal function have been reported in diabetes, aging, and age-related degenerative diseases. These lysosomal abnormalities are an early manifestation of neurodegenerative diseases and often precede the onset of clinical symptoms such as learning and memory deficits; however,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cathepsin D
Share to Fluorescence
Share to Hexosaminidase A

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Hyperglycemia

Share to Intracellular Membranes

Share to Pioglitazone

Share to Staining and Labeling

Share to Thiazolidinediones

Source

Open in PubMed Open full text

Identifiers

PMID: 25976368
DOI: 10.1007/s12035-015-9207-1
PMCID: PMC4644712

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-25976368-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 10 closest

The Role of Oxidized Cholesterol in Diabetes-Induced Lysosomal Dysfunction in the Brain.PMID 25976368Read ↗

Broken Balance: Emerging Cross-Talk Between Proteostasis and Lipostasis in Neurodegenerative DiseasesSemantic proximity Read ↗

Defective Lysosomal Lipid Catabolism as a Common Pathogenic Mechanism for Dementia.Semantic proximity Read ↗

The neuronal endosomal-lysosomal system in Alzheimer's diseaseSemantic proximity Read ↗

Genetic defects in the sphingolipid degradation pathway and their effects on microglia in neurodegenerative disease.Semantic proximity Read ↗

The neuropathogenic contributions of lysosomal dysfunctionSemantic proximity Read ↗

The lysosome system is severely impaired in a cellular model of neurodegeneration induced by HSV-1 and oxidative stress.Semantic proximity Read ↗

Diabetes Promotes Development of Alzheimer’s Disease Through Suppression of AutophagySemantic proximity Read ↗

Deficiency of Lipoprotein Lipase in Neurons Decreases AMPA Receptor Phosphorylation and Leads to Neurobehavioral Abnormalities in Mice.Semantic proximity Read ↗

Sensitivity to lysosome-dependent cell death is directly regulated by lysosomal cholesterol content.Semantic proximity Read ↗

Lysosomal enzyme tripeptidyl peptidase 1 plays a role in degradation of beta amyloid fibrilsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.