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Article

The lysosome system is severely impaired in a cellular model of neurodegeneration induced by HSV-1 and oxidative stress.

Neurobiology of aging - 1 Aug 2018

Kristen Henrike, Sastre Isabel, Muñoz-Galdeano Teresa, Recuero Maria, Aldudo Jesus, Bullido Maria J

Abstract excerpt

The causal agent(s) and molecular mechanisms of Alzheimer's disease (AD) remain unclear. Mounting evidence suggests that herpes simplex virus type 1 (HSV-1) infection is involved in the AD pathogenesis. Oxidative stress (OS) may also be crucial in the AD development. Our group previously reported that both HSV-1 and OS trigger the appearance of AD-type neurodegeneration markers. The main aim of the present study...

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Identifiers

PMID: 29689425
DOI: 10.1016/j.neurobiolaging.2018.03.025

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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