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Article

Sensitivity to lysosome-dependent cell death is directly regulated by lysosomal cholesterol content.

PloS one - 1 Jan 2012

Appelqvist Hanna, Sandin Linnea, Björnström Karin, Saftig Paul, Garner Brett, Ollinger Karin, Kågedal Katarina

Abstract excerpt

Alterations in lipid homeostasis are implicated in several neurodegenerative diseases, although the mechanisms responsible are poorly understood. We evaluated the impact of cholesterol accumulation, induced by U18666A, quinacrine or mutations in the cholesterol transporting Niemann-Pick disease type C1 (NPC1) protein, on lysosomal stability and sensitivity to lysosome-mediated cell death. We found that neurons...

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Identifiers

PMID: 23166840
DOI: 10.1371/journal.pone.0050262
PMCID: PMC3500374

Genes

NPC1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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