Article
Application of family-based association testing to assess the genotype-phenotype association involved in complex traits using single-nucleotide polymorphisms.
BMC genetics - 30 Dec 2005
Wang Ming-Hsi, Guo Mitchell, Shugart Yin Y
Abstract excerpt
BACKGROUND: We used the FBAT (family-based association test) software to test for association between 300 individual single-nucleotide polymorphisms and P1 (a latent trait of Kofendred Personality Disorder) in 100 simulated replicates of the Aipotu population. Using the Genetic Analysis Workshop 14 dataset, we calculated the power of FBAT to detect linkage disequilibrium on chromosome 3 (D2). Also, we calculated...
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