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Article

Rosetta comparative modeling for library design: Engineering alternative inducer specificity in a transcription factor.

Proteins - 1 Jul 2015

Jha Ramesh K, Chakraborti Subhendu, Kern Theresa L, Fox David T, Strauss Charlie E M

Abstract excerpt

Structure-based rational mutagenesis for engineering protein functionality has been limited by the scarcity and difficulty of obtaining crystal structures of desired proteins. On the other hand, when high-throughput selection is possible, directed evolution-based approaches for gaining protein functionalities have been random and fortuitous with limited rationalization. We combine comparative modeling of dimer...

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PMID: 25974100
DOI: 10.1002/prot.24828

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