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Article

Computational design of a chain-specific tetracycline repressor heterodimer.

Journal of molecular biology - 29 Oct 2010

Stiebritz Martin T, Wengrzik Stefanie, Klein Doris L, Richter Jan Paul, Srebrzynski Anna, Weiler Sigrid, Muller Yves A

Abstract excerpt

The specificity and selectivity of protein-protein interactions are of central importance for many biological processes, including signal transduction and transcription control. We used the in-house side-chain packing program MUMBO to computationally design a chain-specific heterodimeric variant...

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Identifiers

PMID: 20816982
DOI: 10.1016/j.jmb.2010.07.055

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20816982-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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