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Article

IPRO: an iterative computational protein library redesign and optimization procedure.

Biophysical journal - 1 Jun 2006

Saraf Manish C, Moore Gregory L, Goodey Nina M, Cao Vania Y, Benkovic Stephen J, Maranas Costas D

Abstract excerpt

A number of computational approaches have been developed to reengineer promising chimeric proteins one at a time through targeted point mutations. In this article, we introduce the computational procedure IPRO (iterative protein redesign and optimization procedure) for the redesign of an entire combinatorial protein library in one step using energy-based scoring functions. IPRO relies on identifying mutations in...

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Identifiers

PMID: 16513775
DOI: 10.1529/biophysj.105.079277
PMCID: PMC1459523

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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