Article
Isolation and Analysis of Rare Norovirus Recombinants from Coinfected Mice Using Drop-Based Microfluidics.
Journal of virology - 1 Aug 2015
Zhang Huidan, Cockrell Shelley K, Kolawole Abimbola O, Rotem Assaf, Serohijos Adrian W R, Chang Connie B, Tao Ye, Mehoke Thomas S, Han Yulong, Lin Jeffrey S, Giacobbi Nicholas S, Feldman Andrew B, Shakhnovich Eugene, Weitz David A, Wobus Christiane E, Pipas James M
Abstract excerpt
UNLABELLED: Human noroviruses (HuNoVs) are positive-sense RNA viruses that can cause severe, highly infectious gastroenteritis. HuNoV outbreaks are frequently associated with recombination between circulating strains. Strain genotyping and phylogenetic analyses show that noroviruses often recombine in a highly conserved region near the junction of the viral polyprotein (open reading frame 1 [ORF1]) and capsid...
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