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A Digital PCR Assay for Fetal Fraction Quantification Using Multiplex SNP and Y Chromosome Detection.

Clinical chemistry - 3 Aug 2026

Tan Chianru, Dai Peng, Zhao Zhuoyu, Chen Xinwen, Wang Dong, Ren Xiaojing, Zhu Lingxiang, Yan Tizhen, Lou Jiwu, Kong Xiangdong, Guo Yong

Abstract excerpt

BACKGROUND: Fetal fraction (FF) quantification is critical for prenatal cell-free DNA screening. Current methods based on Y chromosome (chrY), differential methylation, or single-nucleotide polymorphisms (SNPs) face limitations including sex dependency, complex workflows, or the need for parental genotyping. An FF quantification method that integrates directly into the digital polymerase chain reaction (dPCR)...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 41740617
DOI: 10.1093/clinchem/hvag017

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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