Article

Visual function restoration in genetically blind mice via endogenous cellular reprogramming

2020-04-08

Abstract excerpt

In this study, we developed an in-situ cellular reprogramming strategy for potent restoration of vision in advanced/end-stage retinitis pigmentosa (RP). Via repressing PTB, an RNA binding protein critical for converting non-neuronal cells to the neuronal lineage, we successfully reprogramed Müller glia to a retinal neuronal fate, and then to cones. We demonstrated that this cellular reprogramming approach was able...

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Literature Corpus work: b1624b15-c176-5b93-b9e8-eaafd36febb4
DOI: 10.1101/2020.04.08.030981

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