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Association of the C677T polymorphism in the methylenetetrahydrofolate reductase gene with breast cancer in a Mexican population.

Genetics and molecular research : GMR - 27 Apr 2015

Ramos-Silva A, Figuera L E, Soto-Quintana O M, Puebla-Pérez A M, Ramírez-Patiño R, Gutiérrez-Hurtado I, Carrillo-Moreno D I, Zúñiga-González G M, Dávalos-Rodríguez I P, Gallegos-Arreola M P

Abstract excerpt

The methylenetetrahydrofolate reductase (MTHFR) gene plays an important role in the steps involved in the processing of amino acids. The analysis of polymorphisms in the MTHFR gene has revealed associations with cancer; in particular the C677T polymorphism, which has been suggested to affect folate metabolism, DNA methylation, synthesis, and repair, and to contribute to tumor promotion in the mammary gland. We...

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Identifiers

PMID: 25966173
DOI: 10.4238/2015.April.27.16

Genes

MTHFR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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