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Article

Role of MTHFR C677T and MTR A2756G polymorphisms in thyroid and breast cancer development.

Genetics and molecular research : GMR - 9 May 2016

Zara-Lopes T, Gimenez-Martins A P A, Nascimento-Filho C H V, Castanhole-Nunes M M U, Galbiatti-Dias A L S, Padovani-Júnior J A, Maniglia J V, Francisco J L E, Pavarino E C, Goloni-Bertollo E M

Abstract excerpt

Folate metabolism is essential for DNA synthesis and repair. Alterations in genes that participate in folate metabolism can be associated with several types of malignant neoplasms, including thyroid and breast cancer. In the present case-control study, we examined the association between methylenetetrahydrofolate reductase (MTHFR C677T, rs1801133) and methionine synthase (MTR A2756G, rs1805087) polymorphisms and...

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Identifiers

PMID: 27173331
DOI: 10.4238/gmr.15028222

Genes

MTHFR
MTR

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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