An acidic microenvironment sets the humoral pattern recognition molecule PTX3 in a tissue repair mode.

doi:10.1084/jem.20141268

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Article

An acidic microenvironment sets the humoral pattern recognition molecule PTX3 in a tissue repair mode.

The Journal of experimental medicine - 1 Jun 2015

Doni Andrea, Musso Tiziana, Morone Diego, Bastone Antonio, Zambelli Vanessa, Sironi Marina, Castagnoli Carlotta, Cambieri Irene, Stravalaci Matteo, Pasqualini Fabio, Laface Ilaria, Valentino Sonia, Tartari Silvia, Ponzetta Andrea, Maina Virginia, Barbieri Silvia S, Tremoli Elena, Catapano Alberico L, Norata Giuseppe D, Bottazzi Barbara, Garlanda Cecilia, Mantovani Alberto

Abstract excerpt

Pentraxin 3 (PTX3) is a fluid-phase pattern recognition molecule and a key component of the humoral arm of innate immunity. In four different models of tissue damage in mice, PTX3 deficiency was associated with increased fibrin deposition and persistence, and thicker clots, followed by increased collagen deposition, when compared with controls. Ptx3-deficient macrophages showed defective pericellular fibrinolysis...

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PMID: 25964372
DOI: 10.1084/jem.20141268
PMCID: PMC4451130

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PTX3

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