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Article

Molecular mechanism for USP7-mediated DNMT1 stabilization by acetylation.

Nature communications - 11 May 2015

Cheng Jingdong, Yang Huirong, Fang Jian, Ma Lixiang, Gong Rui, Wang Ping, Li Ze, Xu Yanhui

Abstract excerpt

DNMT1 is an important epigenetic regulator that plays a key role in the maintenance of DNA methylation. Here we determined the crystal structure of DNMT1 in complex with USP7 at 2.9 Å resolution. The interaction between the two proteins is primarily mediated by an acidic pocket in USP7 and Lysine...

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Source

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Identifiers

PMID: 25960197
DOI: 10.1038/ncomms8023
PMCID: PMC4432644

Genes

DNMT1
USP7

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-25960197-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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