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Article

ADAMTS and ADAMTSL Mutations in Connective Tissue Disorders.

Physiology (Bethesda, Md.) - 1 Nov 2026

Alcocer Ana D, Rush Elizabeth H, Mead Timothy J

Abstract excerpt

The a disintegrin and metalloproteinase with thrombospondin motifs (ADAMTS) family is made up of extracellular matrix (ECM) proteins and enzymes involved in regulating tissue structure and function. The ECM is a network of proteins and polysaccharides surrounding the cells that provide support and maintain cellular function. Mutations to proteins in the ECM lead to systemic connective tissue disorders by...

Read the complete abstract on PubMed

Topics

Humans
Connective Tissue Diseases
ADAMTS Proteins
Mutation
ADAM Proteins
Animals
Extracellular Matrix

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Open in PubMed Open full text

Identifiers

PMID: 41915433
DOI: 10.1152/physiol.00043.2025
PMCID: PMC13157330

Genes

ADAMTS10
ADAMTS17
ADAMTS19
ADAMTS2
ADAMTS6
ADAMTSL2
ADAMTSL4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 20 Oct 2026.

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