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Article

Genetic variation in surfactant protein-A2 alters responses to ozone.

PloS one - 1 Jan 2021

Pederson William P, Cyphert-Daly Jaime M, Tighe Robert M, Que Loretta G, Ledford Julie G

Abstract excerpt

BACKGROUND: Increased exposure to Ozone (O3) is associated with adverse health effects in individuals afflicted with respiratory diseases. Surfactant protein-A (SP-A), encoded by SP-A1 and SP-A2, is the largest protein component in pulmonary surfactant and is functionally impaired by O3-oxidation. OBJECTIVE: We used humanized SP-A2 transgenic mice with allelic variation corresponding to a glutamine (Q) to lysine...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 33617569
DOI: 10.1371/journal.pone.0247504
PMCID: PMC7899376

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