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Article

Differential Impact of Co-expressed SP-A1/SP-A2 Protein on AM miRNome; Sex Differences

16 Aug 2019

Abstract excerpt

In humans there are two surfactant protein A (SP-A) functional genes SFTPA1 and SFTPA2 encoding innate immune molecules, SP-A1 and SP-A2, respectively, with numerous genetic variants each. SP-A interacts and regulates many of the functions of alveolar macrophages (AM). It is shown that SP-A variants differ in their ability to regulate the AM miRNome in response to oxidative stress (OxS). Because humans have both...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 31475015
DOI: 10.3389/fimmu.2019.01960

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