Article
HaploShare: identification of extended haplotypes shared by cases and evaluation against controls.
Genome biology - 9 May 2015
Ying Dingge, Sham Pak Chung, Smith David Keith, Zhang Lu, Lau Yu Lung, Yang Wanling
Abstract excerpt
Recent founder mutations may play important roles in complex diseases and Mendelian disorders. Detecting shared haplotypes that are identical by descent (IBD) could facilitate discovery of these mutations. Several programs address this, but are usually limited to detecting pair-wise shared haplotypes and not providing a comparison of cases and controls. We present a novel algorithm and software package,...
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