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Article

Natural polymorphism S119R of HIV-1 integrase enhances primary INSTI resistance.

Antiviral research - 1 Jul 2015

Hachiya Atsuko, Ode Hirotaka, Matsuda Masakazu, Kito Yumiko, Shigemi Urara, Matsuoka Kazuhiro, Imamura Junji, Yokomaku Yoshiyuki, Iwatani Yasumasa, Sugiura Wataru

Abstract excerpt

Integrase strand transfer inhibitors (INSTIs), which block proviral DNA integration into the host chromosome, are clinically effective against HIV-1 isolates exhibiting resistance to other classes of antiretroviral agents. Although naturally occurring amino acid variation has been less frequently observed in the integrase region, the functional constraints of this variation on primary INSTI resistance-associated...

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PMID: 25956162
DOI: 10.1016/j.antiviral.2015.04.014

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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