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Article

Lack of impact of pre-existing T97A HIV-1 integrase mutation on integrase strand transfer inhibitor resistance and treatment outcome.

PloS one - 1 Jan 2017

Abram Michael E, Ram Renee R, Margot Nicolas A, Barnes Tiffany L, White Kirsten L, Callebaut Christian, Miller Michael D

Abstract excerpt

T97A is an HIV-1 integrase polymorphism associated with integrase strand transfer inhibitor (INSTI) resistance. Using pooled data from 16 clinical studies, we investigated the prevalence of T97A (pre-existing and emergent) and its impact on INSTI susceptibility and treatment response in INSTI-naive patients who enrolled on elvitegravir (EVG)- or raltegravir (RAL)-based regimens. Prior to INSTI-based therapy,...

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Source

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Identifiers

PMID: 28212411
DOI: 10.1371/journal.pone.0172206
PMCID: PMC5315389

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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