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Article

Genetic barrier to the development of resistance to integrase inhibitors in HIV-1 subtypes CRF01_AE and B.

Intervirology - 1 Jan 2012

Nguyen Hai Le, Ruxrungtham Kiat, Delaugerre Constance

Abstract excerpt

OBJECTIVE: The genetic barrier for the evolution of integrase inhibitors (INIs) including raltegravir (RAL), elvitegravir (EVG), and dolutegravir (DTG) resistance was compared between HIV-1 subtypes CRF01_AE and B. METHODS: Analysis of 66 substitutions associated with INI resistance at 41 amino acid positions in 144 nucleotide sequences (109 HIV-1 subtype CRF01_AE and 35 HIV-1 subtype B) of integrase-coding...

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PMID: 22456540
DOI: 10.1159/000336658

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