Article
Assessing the Probability that a Finding Is Genuine for Large-Scale Genetic Association Studies.
PloS one - 1 Jan 2015
Kuo Chia-Ling, Vsevolozhskaya Olga A, Zaykin Dmitri V
Abstract excerpt
Genetic association studies routinely involve massive numbers of statistical tests accompanied by P-values. Whole genome sequencing technologies increased the potential number of tested variants to tens of millions. The more tests are performed, the smaller P-value is required to be deemed significant. However, a small P-value is not equivalent to small chances of a spurious finding and significance thresholds...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.