Article
A novel quantitative hemolytic assay coupled with restriction fragment length polymorphisms analysis enabled early diagnosis of atypical hemolytic uremic syndrome and identified unique predisposing mutations in Japan.
PloS one - 1 Jan 2015
Yoshida Yoko, Miyata Toshiyuki, Matsumoto Masanori, Shirotani-Ikejima Hiroko, Uchida Yumiko, Ohyama Yoshifumi, Kokubo Tetsuro, Fujimura Yoshihiro
Abstract excerpt
For thrombotic microangiopathies (TMAs), the diagnosis of atypical hemolytic uremic syndrome (aHUS) is made by ruling out Shiga toxin-producing Escherichia coli (STEC)-associated HUS and ADAMTS13 activity-deficient thrombotic thrombocytopenic purpura (TTP), often using the exclusion criteria for secondary TMAs. Nowadays, assays for ADAMTS13 activity and evaluation for STEC infection can be performed within a few...
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