Article
Analysis of genetic and predisposing factors in Japanese patients with atypical hemolytic uremic syndrome.
Molecular immunology - 1 Jun 2013
Fan Xinping, Yoshida Yoko, Honda Shigenori, Matsumoto Masanori, Sawada Yugo, Hattori Motoshi, Hisanaga Shuichi, Hiwa Ryosuke, Nakamura Fumihiko, Tomomori Maiko, Miyagawa Shinichiro, Fujimaru Rika, Yamada Hiroshi, Sawai Toshihiro, Ikeda Yuhachi, Iwata Naoyuki, Uemura Osamu, Matsukuma Eiji, Aizawa Yoshiaki, Harada Hiroshi, Wada Hideo, Ishikawa Eiji, Ashida Akira, Nangaku Masaomi, Miyata Toshiyuki, Fujimura Yoshihiro
Abstract excerpt
Hemolytic uremic syndrome (HUS) is characterized by microangiopathic hemolytic anemia, thrombocytopenia, and renal impairment. Approximately 10% of cases are classified as atypical due to the absence of Shiga toxin-producing bacteria as a trigger. Uncontrolled activation of the complement system plays a role in the pathogenesis of atypical HUS (aHUS). Although many genetic studies on aHUS have been published in...
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