Article
A genome-wide association study of European advanced cancer patients treated with opioids identifies regulatory variants on chromosome 20 associated with pain intensity.
European journal of pain (London, England) - 1 Jan 2025
Minnai Francesca, Shkodra Morena, Noci Sara, Esposito Martina, Brunelli Cinzia, Pigni Alessandra, Zecca Ernesto, Skorpen Frank, Klepstad Pål, Kaasa Stein, Corli Oscar, Pallotti Maria C, Maltoni Marco C, Caraceni Augusto T, Colombo Francesca
Abstract excerpt
BACKGROUND: Opioids in step III of the WHO analgesic ladder are the standard of care for treating cancer pain. However, a significant minority of patients do not benefit from therapy. Genetics might play a role in predisposing patients to a good or poor response to opioids. Here, we investigated this issue by conducting a genome-wide association study (GWAS). METHODS: We genotyped 2057 European advanced cancer...
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