Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Genetic Factors Associated With Pain Severity, Daily Opioid Dose Requirement, and Pain Response Among Advanced Cancer Patients Receiving Supportive Care.

Journal of pain and symptom management - 1 Oct 2021

Yennurajalingam Sriram, Astolfi Annalisa, Indio Valentina, Beccaro Monica, Schipani Angela, Yu Robert, Shete Sanjay, Reyes-Gibby Cielito, Lu Zhanni, Williams Janet L, Yeun Sai-Ching, Anderson Aimee E, Biasco Guido, Bruera Eduardo

Abstract excerpt

BACKGROUND: Current understanding of genetic factors associated with pain severity, and improvement of pain with opioids in advanced cancer patients (AC) is inadequate for delivery of personalized pain therapy (PPT). Therefore, the aim of this study was to determine the genetic factors associated with pain severity, daily opioid dose, and pain response in AC patients receiving supportive care. METHODS: In this...

Topics

Join the communities discussing this publication.

Analgesics, Opioid
Neoplasms
Pain
Polymorphism, Single Nucleotide

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 33848569
DOI: 10.1016/j.jpainsymman.2021.03.024

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Genetic Factors Associated With Pain Severity, Daily Opioid Dose Requirement, and Pain Response Among Advanced Cancer Patients Receiving Supportive Care.PMID 33848569Read ↗

Genetic and pharmacogenomic influences on cancer pain management : A scoping reviewSemantic proximity Read ↗

Cancer Pain is Not One Size Fits All: Evolving from Tradition to PrecisionSemantic proximity Read ↗

Advanced cancer pain: the search for genetic factors correlated with interindividual variability in opioid requirement.Semantic proximity Read ↗

Evaluating the Use of Tumor Bank DNA to Validate Genetic Factors Impacting Opioid Response in Patients with Advanced Cancer.Semantic proximity Read ↗

Understanding the genetic determinants of pain and pain management.Semantic proximity Read ↗

OPRM1 c.118A>G Polymorphism and Duration of Morphine Treatment Associated with Morphine Doses and Quality-of-Life in Palliative Cancer Pain Settings.Semantic proximity Read ↗

Influence from genetic variability on opioid use for cancer pain: a European genetic association study of 2294 cancer pain patients.Semantic proximity Read ↗

A genome-wide association study of European advanced cancer patients treated with opioids identifies regulatory variants on chromosome 20 associated with pain intensity.Semantic proximity Read ↗

Role of genetic polymorphisms on opioid safety and efficacy in cancer pain: A systematic review and meta-analysis.Semantic proximity Read ↗

Genetics and Opioids: Towards More Appropriate Prescription in Cancer PainSemantic proximity Read ↗

A European pharmacogenomic study of the response to opioids in advanced cancer patients identifies germline variants associated with nausea-vomiting side effectSemantic proximity Read ↗

The effects of OPRM1 118A>G on methadone response in pain management in advanced cancer at end of life.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.