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Article

Opioid treatment failure in cancer patients: the role of clinical and genetic factors.

Pharmacogenomics - 1 Aug 2016

Oosten Astrid W, Matic Maja, van Schaik Ron H, Look Maxime P, Jongen Joost L, Mathijssen Ron H, van der Rijt Carin C

Abstract excerpt

AIM: To identify clinical and genetic factors associated with outcome of opioid treatment. PATIENTS & METHODS: We performed an exploratory analysis in a cohort of 353 patients treated with fentanyl, morphine, oxycodone and/or hydromorphone for cancer-related pain, exploring selected clinical and pharmacogenetic factors for a correlation with treatment failure for all and per type of opioid. RESULTS: Use of...

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Source

Identifiers

PMID: 27472837
DOI: 10.2217/pgs-2016-0082

Genes

OPRK1
RHBDF2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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