Article
Multiple Loci modulate opioid therapy response for cancer pain.
Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Jul 2011
Galvan Antonella, Skorpen Frank, Klepstad Pål, Knudsen Anne Kari, Fladvad Torill, Falvella Felicia S, Pigni Alessandra, Brunelli Cinzia, Caraceni Augusto, Kaasa Stein, Dragani Tommaso A
Abstract excerpt
PURPOSE: Patients treated with opioid drugs for cancer pain experience different relief responses, raising the possibility that genetic factors play a role in opioid therapy outcome. In this study, we tested the hypothesis that genetic variations may control individual response to opioid drugs in cancer patients. EXPERIMENTAL DESIGN: We tested 1 million single-nucleotide polymorphisms (SNP) in European cancer...
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