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Article

Association of polymorphisms in ARRB2 and clinical response to methadone for pain in advanced cancer.

Pharmacogenomics - 1 Apr 2022

Ozberk Deniz, Haywood Alison, Sutherland Heidi G, Yu Chieh, Albury Cassie L, Zunk Mathew, George Rani, Good Phillip, Griffiths Lyn R, Hardy Janet, Haupt Larisa M

Abstract excerpt

Background: The prescription of methadone in advanced cancer poses multiple challenges due to the considerable interpatient variation seen in effective dose and toxicity. Previous reports have suggested that ARRB2 influences the response to methadone in opioid substitution therapy. Associations with opioid response for pain management in advanced cancer are conflicting, with no studies including methadone as the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 35189719
DOI: 10.2217/pgs-2021-0139

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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