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Article

The functional A allele was resurrected via recombination in the human ABO blood group gene.

Molecular biology and evolution - 1 Jul 2012

Kitano Takashi, Blancher Antoine, Saitou Naruya

Abstract excerpt

Functional A and B alleles are distinguished at two critical sites in exon 7 of the human ABO blood group gene. The most frequent nonfunctional O alleles have one-base deletion in exon 6 producing a frameshift, and it has the A type signature in two critical sites in exon 7. Previous studies indicated that B and O alleles were derived from A allele in human lineage. In this study, we conducted a phylogenetic...

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Identifiers

PMID: 22319172
DOI: 10.1093/molbev/mss021

Genes

ABO

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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